Table of Contents

Definition of Cannabis Withdrawal

Cannabis withdrawal refers to a range of physical, emotional, and behavioral symptoms that occur when someone who has been using cannabis regularly reduces or stops their consumption abruptly. While cannabis withdrawal symptoms are typically not life-threatening, they can be uncomfortable and challenging for individuals who have developed a dependence on the substance.

Symptoms of cannabis withdrawal may include:

  • Irritability
  • Anxiety
  • Changes in mood, such as depression or mood swings
  • Sleep disturbances, including insomnia or vivid dreams
  • Decreased appetite or weight loss
  • Physical discomforts like headaches, sweating, or tremors
  • Restlessness
  • Cravings for cannabis

These symptoms usually peak within the first week after discontinuation and gradually subside over a few weeks. However, the duration and severity of withdrawal symptoms can vary from person to person based on factors such as frequency of use, dosage, individual physiology, and the presence of any co-occurring mental health conditions.

It’s important to note that while cannabis withdrawal symptoms are generally mild compared to withdrawal from other substances, they can still be distressing. Seeking support from healthcare professionals or addiction specialists can be beneficial for managing symptoms and facilitating a smoother transition during the withdrawal process.


History of Cannabis Withdrawal

Cannabis has been used for thousands of years for various purposes, including medicinal, recreational, and religious practices. However, the understanding and recognition of cannabis withdrawal as a distinct phenomenon are relatively more recent and have evolved as scientific research on the effects of cannabis on the body and brain has advanced.

  • Historically, the recognition of withdrawal symptoms associated with cannabis was not extensively documented or understood due to various factors, including the social acceptance of the substance and limited scientific research on its effects.
  • In the late 20th century and early 21st century, as scientific understanding of cannabis and its effects improved, researchers began to explore the potential for cannabis dependence and withdrawal. Studies and clinical observations started to document withdrawal symptoms associated with heavy and prolonged cannabis use.
  • In 2013, the American Psychiatric Association included Cannabis Withdrawal Syndrome as a condition for further study in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). This acknowledgment within the DSM-5 represented a significant step in recognizing and understanding cannabis withdrawal as a legitimate phenomenon within the realm of mental health and substance use disorders.
  • Research has since continued to shed light on the nature of cannabis withdrawal, its symptoms, and its prevalence among individuals who use cannabis regularly. This ongoing investigation has led to a better understanding of the timeline, severity, and variability of withdrawal symptoms experienced by those who discontinue or reduce cannabis use.

However, compared to withdrawal from certain other substances, cannabis withdrawal symptoms are generally considered less severe and debilitating. Despite this, recognizing and addressing cannabis withdrawal as part of substance use disorders is crucial for providing appropriate support and treatment to individuals who may experience these symptoms upon cessation of cannabis use.

DSM-5 Criteria of Cannabis Withdrawal

In the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), Cannabis Withdrawal is classified as a condition that requires further study and investigation. It is categorized under “Cannabis-Related Disorders” and is referred to as Cannabis Withdrawal Syndrome.

The DSM-5 doesn’t provide specific diagnostic criteria for Cannabis Withdrawal Syndrome, but it does outline a list of potential symptoms associated with cannabis withdrawal that clinicians may consider when assessing an individual’s condition. These symptoms commonly occur upon cessation or reduction of heavy and prolonged cannabis use.

The DSM-5 mentions that Cannabis Withdrawal Syndrome may include at least three of the following symptoms within a week of reducing or stopping cannabis use:

  • Irritability, anger, or aggression
  • Nervousness or anxiety
  • Sleep difficulties (insomnia, strange dreams, etc.)
  • Appetite or weight changes
  • Restlessness or feeling keyed up or on edge
  • Depressed mood
  • Physical symptoms such as stomach pain, shakiness, sweating, or fever

Additionally, the symptoms must cause significant distress or impairment in social, occupational, or other important areas of functioning.

It’s important to note that while the DSM-5 acknowledges Cannabis Withdrawal Syndrome, the recognition of this condition and its inclusion in the manual does not equate to a formal diagnosis or established criteria akin to other well-defined disorders listed in the DSM-5. As such, the criteria for Cannabis Withdrawal Syndrome are considered for further study and may evolve in subsequent editions based on ongoing research and clinical observations.

Etiology of Cannabis Withdrawal

The etiology, or the underlying causes, of cannabis withdrawal involve the complex interactions between various factors, including the pharmacological effects of cannabis on the body, individual differences in physiology, patterns of use, and psychological factors.

Pharmacological Effects of Cannabis:

Cannabis contains compounds known as cannabinoids, notably tetrahydrocannabinol (THC), which is responsible for many of its psychoactive effects. THC interacts with the endocannabinoid system in the brain, affecting neurotransmitter release and receptor activity. Prolonged use can lead to adaptations in this system, resulting in tolerance and dependence.

Development of Tolerance and Dependence:

With regular and prolonged cannabis use, the body can develop a tolerance, requiring larger amounts of the substance to achieve the same effects. Dependence can also develop, wherein the body becomes accustomed to the presence of cannabis, leading to withdrawal symptoms upon reduction or cessation of use.

Individual Factors:

Variations in an individual’s biology and genetics can influence how they respond to cannabis. Factors such as genetic predisposition, co-occurring mental health conditions, and differences in metabolism may impact the likelihood and severity of withdrawal symptoms.

Patterns and Frequency of Use:

The frequency, dosage, and duration of cannabis use can contribute to the development of withdrawal symptoms. Heavy and prolonged use is more likely to result in dependence and subsequent withdrawal symptoms.

Psychological Factors:

Psychological factors, including the user’s motivations for using cannabis, their mental health status, and coping mechanisms, can play a role in the experience of withdrawal symptoms. Anxiety, stress, or underlying psychological conditions might exacerbate the severity of symptoms.

Environmental and Social Factors:

Environmental factors, such as social influences, access to cannabis, and support systems, can impact the development and management of withdrawal symptoms. A supportive environment or access to resources for assistance may influence an individual’s ability to cope with withdrawal.

Understanding the etiology of cannabis withdrawal involves recognizing the interplay between these various factors. Research continues to deepen our understanding of how these factors contribute to the onset and severity of withdrawal symptoms, aiding in the development of more effective strategies for management and treatment.

Theories related to Cannabis Withdrawal

Several theories attempt to explain the mechanisms and processes involved in cannabis withdrawal. These theories offer different perspectives on how and why withdrawal symptoms manifest after discontinuing or reducing cannabis use:

Endocannabinoid System Dysregulation:

Prolonged cannabis use can lead to alterations in the endocannabinoid system, which plays a crucial role in maintaining balance (homeostasis) in the body. Chronic exposure to exogenous cannabinoids like THC may disrupt this system, leading to adaptations. Upon cessation, the body struggles to maintain stability, resulting in withdrawal symptoms.

Neuroadaptation and Tolerance:

Regular use of cannabis can prompt the brain to adapt to its presence. Neuroadaptation occurs as the brain adjusts its functioning to counteract the effects of THC, leading to the development of tolerance. Withdrawal symptoms might arise when the drug is removed, and the brain has to readjust to the absence of THC.

Rebound Effect:

Cannabis use might suppress certain neurotransmitter systems. When cannabis consumption stops, these systems rebound, becoming hyperactive, which could contribute to withdrawal symptoms. For instance, increased activity in stress-related pathways might result in heightened anxiety during withdrawal.

Psychological and Behavioral Factors:

Psychological factors, such as conditioned responses to the cues associated with cannabis use, expectations about withdrawal, and coping strategies, can influence the severity and experience of withdrawal symptoms. Negative emotions or stress might exacerbate these symptoms.

Individual Variations in Sensitivity:

Genetic, physiological, and psychological differences among individuals can affect their susceptibility to developing cannabis dependence and experiencing withdrawal symptoms. Variations in endocannabinoid system function or genetic predispositions might contribute to differences in withdrawal experiences.

Cross-tolerance and Polysubstance Use:

People who use multiple substances, such as alcohol, nicotine, or other drugs, might experience cross-tolerance. This phenomenon occurs when tolerance to one substance influences the response to another. Polysubstance use can complicate withdrawal symptoms due to these interactions.

Understanding these theories helps researchers and clinicians gain insights into the mechanisms underlying cannabis withdrawal. Research continues to explore these theories to develop more effective interventions and treatments to manage cannabis withdrawal symptoms and address cannabis use disorder.

Risk factors of Cannabis Withdrawal

Several risk factors can contribute to the likelihood and severity of cannabis withdrawal symptoms. These factors can influence how an individual responds when they reduce or discontinue their cannabis use:

Frequency and Duration of Use:

Heavy and prolonged cannabis use is associated with an increased risk of developing dependence and experiencing more pronounced withdrawal symptoms upon cessation. Regular, long-term use can lead to tolerance and neuroadaptations that contribute to withdrawal.

Higher THC Content:

Cannabis products with higher concentrations of THC (tetrahydrocannabinol), the psychoactive compound in cannabis, may lead to a greater likelihood of dependence and more severe withdrawal symptoms.

Early Onset of Use:

Initiating cannabis use at a young age, particularly during adolescence when the brain is still developing, can increase the risk of developing dependence and experiencing withdrawal symptoms. Early exposure might disrupt normal brain development and increase vulnerability to addiction.

Genetic Predisposition:

Genetic factors can influence an individual’s susceptibility to cannabis dependence and withdrawal symptoms. Variations in genes related to the endocannabinoid system or neurotransmitter pathways may contribute to differences in how individuals respond to cannabis.

Co-occurring Mental Health Conditions:

Individuals with pre-existing mental health conditions, such as anxiety, depression, or other substance use disorders, may be more susceptible to developing cannabis dependence and experiencing exacerbated withdrawal symptoms.

Psychosocial Factors:

Environmental influences, such as a lack of social support, stressful life events, peer pressure, or living in an environment where cannabis use is prevalent, can increase the risk of developing problematic cannabis use and difficulties during withdrawal.

Withdrawal Expectations and Coping Mechanisms:

One’s expectations regarding withdrawal and the strategies they use to cope with symptoms can influence the severity of the experience. Negative expectations or a lack of effective coping mechanisms might exacerbate withdrawal symptoms.

Polysubstance Use:

Using multiple substances concurrently, such as alcohol, nicotine, or other drugs, can complicate withdrawal experiences and increase the severity of symptoms due to interactions between substances and cross-tolerance.

Recognizing these risk factors is crucial in identifying individuals who might be more vulnerable to cannabis withdrawal and in developing tailored interventions and support systems to address their specific needs during the withdrawal process.

Treatment for Cannabis Withdrawal

Treatment for cannabis withdrawal focuses on managing symptoms, supporting individuals through the withdrawal process, and addressing underlying issues related to cannabis use disorder. Here are several approaches and interventions commonly utilized:

Supportive Counseling:

Engaging in behavioral therapies, such as cognitive-behavioral therapy (CBT) or motivational enhancement therapy, can help individuals address problematic behaviors, manage cravings, and develop coping strategies to deal with withdrawal symptoms and prevent relapse.


While there are no specific medications approved for treating cannabis withdrawal, some medications may help manage certain symptoms. For instance, antidepressants or anti-anxiety medications might be prescribed to alleviate mood-related symptoms during withdrawal.

Support Groups and Peer Counseling:

Participating in support groups or peer counseling programs, such as 12-step programs or group therapy sessions, can provide a supportive environment where individuals can share experiences, receive encouragement, and learn from others facing similar challenges.

Gradual Reduction:

A tapering or gradual reduction approach, under the supervision of a healthcare professional, involves slowly decreasing cannabis use to minimize withdrawal symptoms. This method can help manage discomfort and make the withdrawal process more manageable.

Lifestyle Changes:

Encouraging healthy lifestyle modifications, such as regular exercise, adequate sleep, stress reduction techniques (like mindfulness or meditation), and a balanced diet, can support overall well-being and assist in managing withdrawal symptoms.

Education and Support Networks:

Providing education about cannabis use disorder, its effects, and the withdrawal process can empower individuals to understand their condition better. Encouraging the involvement of family and friends in providing support is also beneficial.

Medical Monitoring and Support:

Healthcare professionals can monitor individuals going through withdrawal to manage any severe symptoms and address potential complications. They can also offer guidance on self-care strategies and provide medical assistance if needed.

Dual Diagnosis Treatment:

For individuals with co-occurring mental health disorders or polysubstance use, integrated treatment that addresses both the cannabis use disorder and other conditions simultaneously is essential for comprehensive care.

It’s crucial to note that treatment approaches may vary based on individual needs, the severity of withdrawal symptoms, and any co-existing conditions. Seeking professional help from healthcare providers, addiction specialists, or counselors can provide personalized guidance and support for managing cannabis withdrawal effectively.

Therapies for Cannabis Withdrawal

Several therapeutic approaches can be beneficial in managing cannabis withdrawal symptoms and addressing underlying issues related to cannabis use disorder:

Cognitive-Behavioral Therapy (CBT):

CBT is one of the most widely used and effective therapies for substance use disorders, including cannabis use disorder. It helps individuals identify and change problematic thoughts, behaviors, and patterns related to cannabis use. CBT can assist in developing coping strategies, managing cravings, and preventing relapse.

Motivational Enhancement Therapy (MET):

MET focuses on enhancing an individual’s motivation and commitment to change their behavior. It helps individuals explore their motivations for quitting cannabis, resolve ambivalence about change, and set achievable goals toward recovery.

Contingency Management:

This approach involves providing rewards or incentives for achieving and maintaining abstinence from cannabis. It reinforces positive behaviors, such as staying drug-free, attending counseling sessions, or participating in support groups.

Mindfulness-Based Interventions:

Mindfulness techniques, such as mindfulness meditation or mindfulness-based relapse prevention (MBRP), can help individuals increase awareness of their thoughts, emotions, and cravings without judgment. These practices can assist in managing stress, reducing cravings, and preventing relapse.

Family-Based Therapy:

Involving family members in therapy can provide support and improve communication within the family system. Family therapy can help address familial issues, strengthen relationships, and create a supportive environment conducive to recovery.

Group Therapy and Support Groups:

Participating in group therapy sessions or support groups specific to cannabis use disorder can offer individuals a sense of community, validation, and shared experiences. It provides an opportunity to learn from others and gain support during the recovery process.

Integrated Dual Diagnosis Treatment:

For individuals with co-occurring mental health disorders alongside cannabis use disorder, integrated treatment that addresses both conditions simultaneously is crucial. It combines therapies tailored to each disorder for comprehensive care.


Providing education about cannabis use disorder, its effects on the body and mind, the nature of withdrawal symptoms, and strategies for managing cravings and triggers can empower individuals to understand their condition better and actively participate in their recovery.

These therapies can be utilized alone or in combination based on individual needs, preferences, and the severity of cannabis use disorder. Seeking guidance from qualified mental health professionals or addiction specialists is essential to determine the most suitable therapy or combination of therapies for effective cannabis withdrawal management and long-term recovery.

Preventions of Cannabis Withdrawal

Preventing cannabis withdrawal involves strategies aimed at reducing the likelihood of developing dependence and minimizing the severity of withdrawal symptoms for those already using the substance. Here are some preventive measures:

Moderation and Responsible Use:

Using cannabis in moderation and avoiding heavy or frequent use can reduce the risk of developing dependence and tolerance, thereby lessening the severity of potential withdrawal symptoms.

Setting Limits:

Establishing personal limits on cannabis use, such as frequency, dosage, and situations for use, can help prevent excessive consumption and reduce the risk of dependence.

Regular Breaks and Tolerance Management:

Taking regular breaks from cannabis use, even for short periods, can prevent the body from developing tolerance and dependence. This approach helps in managing withdrawal symptoms if they occur.

Mindful Use and Awareness:

Being mindful of the reasons for using cannabis and staying aware of its effects can help individuals recognize any developing patterns of problematic use and take proactive steps to address them before dependence occurs.

Addressing Underlying Issues:

Identifying and addressing underlying factors contributing to cannabis use, such as stress, mental health conditions, or environmental triggers, can help prevent reliance on cannabis as a coping mechanism.

Avoiding Polydrug Use:

Refraining from using multiple substances concurrently can reduce the risk of interactions between substances and the development of cross-tolerance, which can complicate withdrawal experiences.

Seeking Support and Education:

Seeking guidance from healthcare professionals or addiction specialists can provide valuable information about the risks associated with cannabis use, ways to prevent dependence, and resources for managing withdrawal symptoms if they arise.

Healthy Lifestyle Choices:

Maintaining a healthy lifestyle that includes regular exercise, proper nutrition, adequate sleep, and stress management techniques can contribute to overall well-being and may mitigate the severity of withdrawal symptoms.

Peer Support and Social Networks:

Building supportive social networks and seeking peer support can provide encouragement, accountability, and alternatives to cannabis use, promoting healthier behaviors and reducing reliance on the substance.

It’s important to note that while these preventive strategies can be beneficial, they might not completely eliminate the risk of cannabis withdrawal, especially in cases of prolonged or heavy use. If an individual experiences problematic cannabis use or withdrawal symptoms, seeking professional help from healthcare providers or addiction specialists is essential for proper assessment and guidance.

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